Metabolic Control of Dendritic Cell Functions: Digesting Information

Metabolic Information Control System

Systems for the integration of data in molecular biology are becoming more and more important because scientists as well as applications can not always find all relevant data in one database. Another advantage of data integration is the possibility to derive information of a new quality using semantic relations between the integrated data of various databases. With the requirement to feed an ap...

Impact of histamine on dendritic cell functions.

A rapidly growing body of evidence highlighted that histamine, a small biogenic amine, is implicated in the regulation of DC (dendritic cell) functions. It is well established that DCs represent the most potent antigen-presenting cells of the body, linking innate and acquired immunity and regulating the outcome of immune responses. Signals, associated with ongoing inflammation and uptake of for...

Circadian Clock Control of Liver Metabolic Functions.

The circadian clock is an endogenous biological timekeeping system that synchronizes physiology and behavior to day/night cycles. A wide variety of processes throughout the entire gastrointestinal tract and notably the liver appear to be under circadian control. These include various metabolic functions such as nutrient uptake, processing, and detoxification, which align organ function to cycle...

Cell Functions Ion Channels Modulating Mouse Dendritic

Metabolic Control of Dendritic Cell Activation and Function: Recent Advances and Clinical Implications

Dendritic cells (DCs) are key regulators of both immunity and tolerance by controlling activation and polarization of effector T helper cell and regulatory T cell responses. Therefore, there is a major focus on developing approaches to manipulate DC function for immunotherapy. It is well known that changes in cellular activation are coupled to profound changes in cellular metabolism. Over the p...